194 papers
Infectious diseases represent one of the most dynamic frontiers in global health, covering everything from seasonal flu outbreaks to emerging viral threats that cross borders. This field focuses on how pathogens spread, how our immune systems respond, and the strategies scientists use to stop infections before they become epidemics. Because the science moves fast, waiting for traditional publication often means missing critical insights that could save lives.
At Gist.Science, we process every new preprint in this category directly from medRxiv to ensure you see the latest findings the moment they appear. Our team transforms these raw studies into both accessible plain-language explanations and detailed technical summaries, bridging the gap between complex research and public understanding. Below are the latest papers in infectious diseases, updated daily with fresh insights from the global research community.
Although infection rates were similar between sexes in Hong Kong, males experienced significantly higher COVID-19 mortality risks across all epidemic waves even after adjusting for vaccination status and pre-existing conditions, a pattern consistent with sex disparities observed in other respiratory diseases.
In a phase 2a randomized controlled trial, the SARS-CoV-2-specific monoclonal antibody AER002 was found to be safe but failed to demonstrate significant efficacy in improving physical health or other outcomes for people with Long COVID, though post-hoc analysis suggested potential benefits for a specific subgroup with lower baseline antibody levels.
This systematic review and individual patient data meta-analysis of 1,797 patients in Indonesia demonstrates that a higher total primaquine dose of 7 mg/kg significantly reduces *Plasmodium vivax* relapse rates compared to the standard 3.5 mg/kg regimen, with only a moderate increase in gastrointestinal discomfort and rare clinically relevant haemolysis among patients with adequate G6PD activity.
This first multicenter study in Western Ethiopia (2021–2025) reveals a rapidly increasing burden of multidrug-resistant MRSA, particularly among children and outpatients, driven by widespread antibiotic misuse and inadequate infection control, thereby highlighting the urgent need for enhanced antimicrobial stewardship and surveillance to guide empiric therapy.
The study presents a developed and optimized, self-collected, field-stable saliva-based immunoassay that demonstrates high correlation with venous blood samples for quantifying pathogen-specific IgG, offering a non-invasive and scalable alternative for global epidemiological surveillance.
In a population-based study in rural Uganda, current *Schistosoma mansoni* infection intensity was found to remain significantly associated with splenomegaly in children and hepatomegaly in adults, even after accounting for co-endemic malaria, HIV, hepatitis B, and repeated praziquantel treatment.
A nationwide home-based test-to-treat program successfully delivered timely and equitable antiviral treatment for COVID-19 and influenza to diverse adults across all 50 states by integrating at-home testing, on-demand telehealth, and flexible medication fulfillment options.
This study develops a delay differential equation model incorporating relapse and multiple time delays to demonstrate that while incubation delays affect epidemic peak timing, relapse is the critical mechanism driving Nipah virus persistence and altering endemic equilibrium conditions beyond the classical reproduction threshold.
Strengthening in-country sequencing capacity in Guinea generated 28 Lassa virus genomes that revealed cross-border transmission dynamics with Liberia and Sierra Leone, highlighting the critical role of enhanced genomic surveillance in guiding future public health actions.
This exploratory study utilized quantitative proteomics on plasma samples from adults with active syphilis and matched controls to identify specific protein signatures that effectively distinguish active disease from prior treatment, suggesting a promising avenue for developing novel diagnostic tools.